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AZ 628 643 Hara-Nishimura I
AZ 628 643 Hara-Nishimura I
AZ 628 643 Hara-Nishimura I
AZ 628 643 Hara-Nishimura I

AZ 628 643 Hara-Nishimura I

SKU: 84334163291

4.7
USD90.00 USD124.00

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AZ 628 643 Hara-Nishimura IAZ 628 is a selective, orally available Raf inhibitor with excellent pharmacokinetic properties and robust tumor growth inhibition in xenograft studies ( (IC50 values are 29, 34 and 105 nM for c Raf1, B RafV600E and wild type B Raf, respectively). AZ 628 inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B RafV600E mutation. Product information CAS Number: 878739 06 1 Molecular Weight: 451. 52

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Description

Hara-Nishimura I

57(5):2033-46

Smiles: CN1N=C(N)C2=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C3=NC=NC1=C23

InChiKey: DECBQELQORZLLP-UAIOPKHMSA-N

2017 Dec 14

AZ 628 643 Hara-Nishimura IAZ 628 is a selective, orally available Raf inhibitor with excellent pharmacokinetic properties and robust tumor growth inhibition in xenograft studies ( (IC50 values are 29, 34 and 105 nM for c Raf1, B RafV600E and wild type B Raf, respectively). AZ 628 inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B RafV600E mutation. Product information CAS Number: 878739 06 1 Molecular Weight: 451. 52

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