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Electrophysiological recordings revealed that exendin-4 increases the frequency of spontaneous excitatory postsynaptic currents (sEPSCs) of VTA dopaminergic neurons suggesting the possible presynaptic modulation of GLP-1R on glutamatergic terminals

This effect is due to an improvement in hepatic clearance and peripheral disposal of glucose in response to a correction of chronic hyperinsulinemia.88,89 However, liver transplantation cures DM only in 67% of cases

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