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CMSs Medicare Benefit Policy Manual expressly provides: FDA approved drugs used for indications other than what is indicated on the official label may be covered under Medicare if the [government contractor] determines the use to be medically accepted, taking into consideration the major drug compendia, authoritative medical literature and/or accepted standards of medical practice. CMSs Manual further provides that [d]eterminations as to whether medication is reasonable and necessary for an individual patient should be made on the same basis as all other such determinations (i.e., with the advice of medical consultants and with reference to accepted standards of medical practice and the medical circumstances of the individual case.)

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