Nilotinib - CAS# 641571-10-0 ndopril and a α10 nAChR antagonist

and a α10 nAChR antagonist found in Panax

RO-3306 downregulated expression of the antiapoptotic proteins Bcl-2 and survivin and blocked p53-mediated induction of p21 and MDM2

ABT-199’s cell-killing effect is selective and mechanism dependent

Perry KW et al

PubMed PMID: 27323403

Nilotinib - CAS# 641571-10-0 ndopril and a α10 nAChR antagonistNilotinib, also known as AMN107, is a small molecule tyrosine kinase inhibitor approved for the treatment of imatinib resistant chronic myelogenous leukemia. Structurally related to imatinib, it was developed based on the structure of the Abl imatinib complex to address imatinib intolerance and resistance. Nilotinib is a selective Bcr Abl kinase inhibitor that is 10 30 fold more potent than imatinib in inhibiting Bcr Abl tyrosine kinase activity and