Pirfenidone - CAS# 53179-13-8 0207 Zagrean AM

Zagrean AM

In all cultured cell types

2/6/24 hours) dramatically decreases the cyclin D-1 mRNA levels in a time-dependent manner in primary HMVEC

InChiKey: LLJJDLHGZUOMQP-UHFFFAOYSA-N

9 nM binding affinity to WDR5

Pirfenidone - CAS# 53179-13-8 0207 Zagrean AMPirfenidone, CAS No. 53179 13 8, is an anti fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II. Pirfenidone has well established antifibrotic and anti inflammatory properties in various in vitro systems and animal models of fibrosis. A number of cell based studies have shown that pirfenidone reduces fibroblast