ATP (disodium salt) Catalog No.:M9163-2 Pyridone 6 interferes with JAK

Pyridone 6 interferes with JAK kinase activity by interacting within the ATP-binding cleft

Xagrid hydrochloride

blocking phosphorylation of Y397 with an IC50 value of about 1 μM

potent and selective inhibitor of the deubiquitinylating enzymes (DUBs)

(2014) ACS Med

ATP (disodium salt) Catalog No.:M9163-2 Pyridone 6 interferes with JAKRO4987655, also known as CH4987655, is an orally active small molecule, targeting mitogen activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK inhibitor RO4987655 binds to and inhibits MEK, which may result in the inhibition of MEK dependent cell signaling and the inhibition of tumor cell proliferation. MEK, a dual specificity threonine tyrosine kinase, is a key component of the RAS RAF MEK ERK signaling