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dBET1 etin 1'-biphenyl]-4-yl)-2
dBET1 etin 1'-biphenyl]-4-yl)-2
dBET1 etin 1'-biphenyl]-4-yl)-2
dBET1 etin 1'-biphenyl]-4-yl)-2

dBET1 etin 1'-biphenyl]-4-yl)-2

SKU: 95918980897

4.8
USD138.00 USD169.00

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Live Spec

dBET1 etin 1'-biphenyl]-4-yl)-2dBET1 is a potent BRD4 degrader (IC50=20 nM), and competitive antagonist of BET bromodomains to hijack the Cereblon E3 ubiquitin ligase complex. dBET1 is a hybrid molecule that combines (+) JQ1 and thalidomide. 1 The JQ1 portion facilitates binding of dBET1 to the bromodomains of BET family transcriptional activators. The thalidomide moiety drives proteasomal degradation, as phthalimides bind cereblon to create a substrate recognition site for E3

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Description

1'-biphenyl]-4-yl)-2

PP-121 also inhibits other PI3Ks including p110α and DNA-PK with IC50 of 52 nM and 60 nM

9% (w/v) saline

PMID: 29669890

l-lactide-co-glycolide) nanospheres

dBET1 etin 1'-biphenyl]-4-yl)-2dBET1 is a potent BRD4 degrader (IC50=20 nM), and competitive antagonist of BET bromodomains to hijack the Cereblon E3 ubiquitin ligase complex. dBET1 is a hybrid molecule that combines (+) JQ1 and thalidomide. 1 The JQ1 portion facilitates binding of dBET1 to the bromodomains of BET family transcriptional activators. The thalidomide moiety drives proteasomal degradation, as phthalimides bind cereblon to create a substrate recognition site for E3

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