CYC-116 0-IN-1 Sodium ionophore III

Sodium ionophore III

A novel small-molecule inhibitor of NF-kappaB signaling

SAR439859 shows promising antitumor activity in breast cancer mice xenograft models

27(1):47-56

Wild-type zebrafish embryos were treated with HLY78 at 80 μM from the three-somite stage until 36 h

CYC-116 0-IN-1 Sodium ionophore IIICYC116 is an orally bioavailable small molecule multi kinase inhibitor with antineoplastic activity. Aurora kinase VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. Aurora kinases are serine threonine protein kinases that are only expressed in actively dividing cells and are critical in