Ixabepilone 0160 InChi: InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H

InChi: InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H

Obeticholic acid (INT-747)7 (10 mg/kg) and HS increases the pulmonary congestion in the animals

It has minimal activity (IC50 >1 µM) against HDAC4

InChiKey: ITIXDWVDFFXNEG-JHOUSYSJSA-N

Eskiocak B

Ixabepilone 0160 InChi: InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5HIxabepilone (also known as azaepothilone B, or BMS 247550) is an orally bioavailable microtubule inhibitor. Ixabepilone was a semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2 M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane