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Toxic overload does not explain every case of depression, but oxidative stress, inflammation, mitochondrial dysfunction, medication sensitivity and impaired methylation may contribute to depressive symptoms in selected patients

Microglia with the M1 phenotype can show signs of inflammation under specific environments whereas those with the M2 phenotype generally do not

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The antibody combination was transferred to an ELISA, enabling a more precise and quantitative study of the concentration response to insulin and IGF1 stimulation and determination of EC50 values

For this study, researchers tracked nearly 7,900 patients being treated by the Cleveland Clinic for severe obesity, of whom about 6,100 were prescribed semaglutide and the rest tirzepatide