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No comparative data exist to determine whether this offers any advantage over single-route dosing

A network meta-analysis by Wang et al

Phase 3 data confirms 15.6% average weight loss at 68 weeks - 50% more than semaglutide alone - with synergistic effects producing 20-25% loss in excellent responders

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The arginate (arginine salt) form demonstrates improved stability in gastric acid, making it better suited for oral administration with bioavailability exceeding 90% compared to roughly 3% for standard acetate taken orally

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