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To evaluate whether group differences in histological outcomes remained significant when accounting for subject- or animal-level variability, we reanalyzed all relevant datasets using linear mixed-effects models

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In addition to these anabolic effects, IGF-I-induced activation of PI3K/Akt is also the reported mechanism by which IGF-I inhibits mitochondrial apoptosis (Pang, Zheng, Fan et al., 2007)

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