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Lipid metabolic reprogramming in tumor microenvironment: From mechanisms to therapeutics

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DNA methylation DNA methylation is the process of obtaining methyl groups through the covalent binding of specific DNA sequences under the action of DNA methyltransferase

24 With respect to this, the negative association between frequency of the cSHMT -C1420T variant and latitude documented in this study may indicate that activity of the de novo thymidylate synthesis pathway is increasingly impaired in populations exposed to higher UVR, but the burden of this variant is unclear due to mSHMT likely maintaining cSHMT activity in such cases

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