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As a result, GLP-1 receptor agonists (GLP-1RAs) have been developed

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The FDA rejected Ascendis first attempt for approval of Yorvipath in May 2023, citing manufacturing concerns

Our large-scale nationwide study shows that GLP-1 RAs do not seem linked to a higher risk of suicide or suicide attempts

As a result, significant efforts are being made to develop long-acting GLP-1R agonists, through the substitution of a susceptible amino acid in GLP-1 into a mutant to confer resistance to DPP-IV degradation 12 and the significantly prolonging of GLP-1 half-life via the virtue of the neonatal Fc receptor (FcRn) recycling mechanism through binding to IgG-Fc 13 or human serum albumin (HSA) 14