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SKU: 96802284289

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Biofilms further exacerbate immune dysregulation by fostering an immunosuppressive milieu, enabling bacterial communication, immune evasion, and chronic persistence, thereby increasing the risk of implant failure 8

It is characterized by ROS-induced dissociation of the oxygen-sensitive kinase KEAP1, activating the NRF2 signaling pathway and caspase-8-dependent cell death [241, 242]

Erastin induces considerable apoptosis and reduces the growth capacity of metastatic colorectal cancer, with IC50 values 3-fold lower compared with those of sulfasalazine (SASP), which suggested that erastin is more effective compared with SASP (54)