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ArticlePubMed 174

KarXT (xanomeline-trospium), comprised of muscarinic agonist xanomeline and muscarinic antagonist trospium, is designed to preferentially activate muscarinic receptor in the CNS and ameliorate the peripheral muscarinic side effects

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These include a 24-hour liquid-only diet before the procedure, point-of-care gastric ultrasound immediately before anesthesia when available, adjustment of the anesthesia plan to reduce aspiration risk, and delaying elective procedures when risk is expected to decrease, such as after the dose-escalation phase or resolution of gastrointestinal symptoms