TL 12-186 RD9 Degrader-1 Epub 2015 Jun 17

Epub 2015 Jun 17

with virtually complete inhibition at 10 μM

Smiles: CC1SC2=C(C(=N[C@@H](CC(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N3C[C@@H](O)C[C@H]3C(=O)NCC3C=CC(=CC=3)C3SC=NC=3C)C(C)(C)C)C3=NN=C(C)N23)C2C=CC(Cl)=CC=2)C=1C

Kobayashi M

The monoamine reuptake blocker brasofensine reverses akinesia without dyskinesia in MPTP-treated and levodopa-primed common marmosets

TL 12-186 RD9 Degrader-1 Epub 2015 Jun 17TL12 186 is a multikinase degrading PROTAC. Product information CAS Number: 2250025 88 6 Molecular Weight: 931. 46 Formula: C44H51ClN10O9S Chemical Name: N (2 (2 (2 (4 (4 ((5 Chloro 4 ((2 (isopropylsulfonyl)phenyl)amino)pyrimidin 2 yl)amino)phenyl)piperazin 1 yl)ethoxy)ethoxy)ethyl) 2 ((2 (2, 6 dioxopiperidin 3 yl) 1, 3 dioxoisoindolin 4 yl)amino)acetamide Smiles: